abstract：:: Cancer cells in quiescence (G0 phase) are resistant to death, and re-entry of quiescent cancer cells into the cell-cycle plays an important role in cancer recurrence. Here we show that two p53-responsive miRNAs utilize distinct but complementary mechanisms to promote cancer cell quiescence by facilitating stabilizat...

journal_title：Cancer research

authors： La T,Liu GZ,Farrelly M,Cole N,Feng YC,Zhang YY,Sherwin SK,Yari H,Tabatabaee H,Yan XG,Guo ST,Liu T,Thorne RF,Jin L,Zhang XD

更新日期：2018-12-01 00:00:00

abstract：:Postpartum mammary gland involution is a tissue remodeling event that occurs in all mammals in the absence of nursing or after weaning to return the gland to the pre-pregnant state. The tissue microenvironment created by involution has proven to be tumor promotional. Here we report that the GPI-linked protein semaphor...

journal_title：Cancer research

authors： Elder AM,Tamburini BAJ,Crump LS,Black SA,Wessells VM,Schedin PJ,Borges VF,Lyons TR

更新日期：2018-11-15 00:00:00

abstract：:Cancer is a complex disorder extremely dependent on its microenvironment and highly regulated by multiple intracellular and extracellular stimuli. Studies show that reactive oxygen and nitrogen species (RONS) play key roles in cancer initiation and progression. Accumulation of RONS caused by imbalance between RONS gen...

journal_title：Cancer research

authors： Moldogazieva NT,Lutsenko SV,Terentiev AA

更新日期：2018-11-01 00:00:00

abstract：:Dickkopf3 (DKK3) is a secretory protein that belongs to the DKK family, but exhibits structural divergence from other family members, and its corresponding receptors remain to be identified. Although DKK3 has been shown to have oncogenic functions in certain cancer types, the underlying mechanism by which DKK3 promote...

journal_title：Cancer research

authors： Kajiwara C,Fumoto K,Kimura H,Nojima S,Asano K,Odagiri K,Yamasaki M,Hikita H,Takehara T,Doki Y,Morii E,Kikuchi A

更新日期：2018-11-01 00:00:00

abstract：:Major contributors to therapeutic resistance in pancreatic ductal adenocarcinoma (PDAC) include Kras mutations, a dense desmoplastic stroma that prevents drug delivery to the tumor, and activation of redundant signaling pathways. We have previously identified a mechanistic rationale for targeting STAT3 signaling to ov...

journal_title：Cancer research

authors： Nagathihalli NS,Castellanos JA,Lamichhane P,Messaggio F,Shi C,Dai X,Rai P,Chen X,VanSaun MN,Merchant NB

更新日期：2018-11-01 00:00:00

abstract：:The sodium iodide symporter (NIS) is a classical iodide pump typically localized within the cell plasma membrane in thyroid cells, where NIS expression is believed to ensure success of mainstay radioiodide therapy in thyroid cancers. Although radioiodide uptake is generally reduced in thyroid cancer tissue, intracellu...

journal_title：Cancer research

authors： Feng F,Yehia L,Ni Y,Chang YS,Jhiang SM,Eng C

更新日期：2018-11-01 00:00:00

abstract：:Deletion of endoplasmic reticulum resident chaperone Grp78 results in activation of the unfolded protein response and causes rapid depletion of the entire intestinal epithelium. Whether modest reduction of Grp78 may affect stem cell fate without compromising intestinal integrity remains unknown. Here, we employ a mode...

journal_title：Cancer research

authors： van Lidth de Jeude JF,Spaan CN,Meijer BJ,Smit WL,Soeratram TTD,Wielenga MCB,Westendorp BF,Lee AS,Meisner S,Vermeulen JLM,Wildenberg ME,van den Brink GR,Muncan V,Heijmans J

更新日期：2018-11-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDC) are the main producers of a key T-cell-stimulatory cytokine, IFNα, and critical regulators of antiviral immunity. Chronic myeloid leukemia (CML) is caused by BCR-ABL, which is an oncogenic tyrosine kinase that can be effectively inhibited with ABL-selective tyrosine kinase inhibitors...

journal_title：Cancer research

authors： Inselmann S,Wang Y,Saussele S,Fritz L,Schütz C,Huber M,Liebler S,Ernst T,Cai D,Botschek S,Brendel C,Calogero RA,Pavlinic D,Benes V,Liu ET,Neubauer A,Hochhaus A,Burchert A

更新日期：2018-11-01 00:00:00

abstract：:Advocates bring unique and important viewpoints to the cancer research process, ensuring that scientific and medical advances are patient-centered and relevant. In this article, we discuss the benefits of engaging advocates in cancer research and underscore ways in which both the scientific and patient communities can...

journal_title：Cancer research

authors： Salamone JM,Lucas W,Brundage SB,Holloway JN,Stahl SM,Carbine NE,London M,Greenwood N,Goyes R,Chisholm DC,Price E,Carlin R,Winarsky S,Baker KB,Maues J,Shajahan-Haq AN

更新日期：2018-10-15 00:00:00

abstract：:Microtubule inhibitors as chemotherapeutic drugs are widely used for cancer treatment. However, the development of multidrug resistance (MDR) in cancer is a major challenge for microtubule inhibitors in their clinical implementation. From a high-throughput drug screen using cells transformed by oncogenic RAS, we ident...

journal_title：Cancer research

authors： Ning N,Yu Y,Wu M,Zhang R,Zhang T,Zhu C,Huang L,Yun CH,Benes CH,Zhang J,Deng X,Chen Q,Ren R

更新日期：2018-10-15 00:00:00

abstract：:High expression of VEGFC predicts adverse prognosis in acute myeloid leukemia (AML). We therefore explored VEGFC-targeting efficacy as an AML therapy using a VEGFC mAb. VEGFC antibody therapy enforced myelocytic differentiation of clonal CD34+ AML blasts. Treatment of CD34+ AML blasts with the antibody reduced expansi...

journal_title：Cancer research

authors： Kampen KR,Scherpen FJG,Mahmud H,Ter Elst A,Mulder AB,Guryev V,Verhagen HJMP,De Keersmaecker K,Smit L,Kornblau SM,De Bont ESJM

更新日期：2018-10-15 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, with a high propensity for distant metastasis and limited treatment options, yet its molecular underpinnings remain largely unknown. Microrchidia family CW-type zinc finger 2 (MORC2) is a newly identified chromatin remodeling protein who...

journal_title：Cancer research

authors： Zhang FL,Cao JL,Xie HY,Sun R,Yang LF,Shao ZM,Li DQ

更新日期：2018-10-15 00:00:00

abstract：:Elucidation of the underlying molecular mechanisms of immune evasion in cancer is critical for the development of immunotherapies aimed to restore and stimulate effective antitumor immunity. Here, we evaluate the role of the actin cytoskeleton in breast cancer cell resistance to cytotoxic natural killer (NK) cells. A ...

journal_title：Cancer research

authors： Al Absi A,Wurzer H,Guerin C,Hoffmann C,Moreau F,Mao X,Brown-Clay J,Petrolli R,Casellas CP,Dieterle M,Thiery JP,Chouaib S,Berchem G,Janji B,Thomas C

更新日期：2018-10-01 00:00:00

abstract：:MEK inhibition is of interest in cancer drug development, but clinical activity in metastatic colorectal cancer (mCRC) has been limited. Preclinical studies demonstrated Wnt pathway overexpression in KRAS-mutant cell lines resistant to the MEK inhibitor, selumetinib. The combination of selumetinib and cyclosporin A, a...

journal_title：Cancer research

authors： Krishnamurthy A,Dasari A,Noonan AM,Mehnert JM,Lockhart AC,Leong S,Capasso A,Stein MN,Sanoff HK,Lee JJ,Hansen A,Malhotra U,Rippke S,Gustafson DL,Pitts TM,Ellison K,Davis SL,Messersmith WA,Eckhardt SG,Lieu CH

更新日期：2018-09-15 00:00:00

abstract：:Inflammation affects tumor immune surveillance and resistance to therapy. Here, we show that production of IL1β in primary breast cancer tumors is linked with advanced disease and originates from tumor-infiltrating CD11c+ myeloid cells. IL1β production is triggered by cancer cell membrane-derived TGFβ. Neutralizing TG...

journal_title：Cancer research

authors： Wu TC,Xu K,Martinek J,Young RR,Banchereau R,George J,Turner J,Kim KI,Zurawski S,Wang X,Blankenship D,Brookes HM,Marches F,Obermoser G,Lavecchio E,Levin MK,Bae S,Chung CH,Smith JL,Cepika AM,Oxley KL,Snipes GJ,B

更新日期：2018-09-15 00:00:00

abstract：:CBLC (CBL proto-oncogene c) belongs to the CBL protein family, which has E3 ubiquitin ligase activity toward activated receptor tyrosine kinases. CBLC is frequently upregulated in non-small cell lung cancer (NSCLC), yet very little is known about the functions of CBLC in tumorigenesis. Here we show that CBLC is an epi...

journal_title：Cancer research

authors： Hong SY,Kao YR,Lee TC,Wu CW

更新日期：2018-09-01 00:00:00

abstract：:For many solid tumors, surgical resection remains the gold standard and tumor-involved margins are associated with poor clinical outcomes. Near-infrared (NIR) fluorescence imaging using molecular agents has shown promise for in situ imaging during resection. However, for cancers with difficult imaging conditions, surg...

journal_title：Cancer research

authors： Gao RW,Teraphongphom NT,van den Berg NS,Martin BA,Oberhelman NJ,Divi V,Kaplan MJ,Hong SS,Lu G,Ertsey R,Tummers WSFJ,Gomez AJ,Holsinger FC,Kong CS,Colevas AD,Warram JM,Rosenthal EL

更新日期：2018-09-01 00:00:00

abstract：:Persistent bronchial dysplasia is associated with increased risk of developing invasive squamous cell carcinoma (SCC) of the lung. In this study, we hypothesized that differences in gene expression profiles between persistent and regressive bronchial dysplasia would identify cellular processes that underlie progressio...

journal_title：Cancer research

authors： Merrick DT,Edwards MG,Franklin WA,Sugita M,Keith RL,Miller YE,Friedman MB,Dwyer-Nield LD,Tennis MA,O'Keefe MC,Donald EJ,Malloy JM,van Bokhoven A,Wilson S,Koch PJ,O'Shea C,Coldren C,Orlicky DJ,Lu X,Baron AE,Hickey

更新日期：2018-09-01 00:00:00

abstract：:The ShcA adaptor protein transduces oncogenic signals downstream of receptor tyrosine kinases. We show here that breast tumors engage the ShcA pathway to increase their metabolism. ShcA signaling enhanced glucose catabolism through glycolysis and oxidative phosphorylation, rendering breast cancer cells critically depe...

journal_title：Cancer research

authors： Im YK,Najyb O,Gravel SP,McGuirk S,Ahn R,Avizonis DZ,Chénard V,Sabourin V,Hudson J,Pawson T,Topisirovic I,Pollak M,St-Pierre J,Ursini-Siegel J

更新日期：2018-09-01 00:00:00

abstract：:MRI is the gold standard for confirming a pelvic lymph node metastasis diagnosis. Traditionally, medical radiologists have analyzed MRI image features of regional lymph nodes to make diagnostic decisions based on their subjective experience; this diagnosis lacks objectivity and accuracy. This study trained a faster re...

journal_title：Cancer research

authors： Lu Y,Yu Q,Gao Y,Zhou Y,Liu G,Dong Q,Ma J,Ding L,Yao H,Zhang Z,Xiao G,An Q,Wang G,Xi J,Yuan W,Lian Y,Zhang D,Zhao C,Yao Q,Liu W,Zhou X,Liu S,Wu Q,Xu W,Zhang J,Wang D,Sun Z,Gao Y,Zhang X,Hu J,Zha

更新日期：2018-09-01 00:00:00

abstract：:MAPK signaling pathways are constitutively active in colon cancer and also promote acquired resistance to MEK1 inhibition. Here, we demonstrate that BRAFV600E -mutated colorectal cancers acquire resistance to MEK1 inhibition by inducing expression of the scaffold protein CEMIP through a β-catenin- and FRA-1-dependent ...

journal_title：Cancer research

authors： Duong HQ,Nemazanyy I,Rambow F,Tang SC,Delaunay S,Tharun L,Florin A,Büttner R,Vandaele D,Close P,Marine JC,Shostak K,Chariot A

更新日期：2018-08-15 00:00:00

abstract：:Primary prostate cancer can have extensive microheterogeneity, but its contribution to the later emergence of metastatic castration-resistant prostate cancer (mCRPC) remains unclear. In this study, we microdissected residual prostate cancer foci in radical prostatectomies from 18 men treated with neoadjuvant-intensive...

journal_title：Cancer research

authors： Sowalsky AG,Ye H,Bhasin M,Van Allen EM,Loda M,Lis RT,Montaser-Kouhsari L,Calagua C,Ma F,Russo JW,Schaefer RJ,Voznesensky OS,Zhang Z,Bubley GJ,Montgomery B,Mostaghel EA,Nelson PS,Taplin ME,Balk SP

更新日期：2018-08-15 00:00:00

abstract：:Cetuximab, the FDA-approved anti-EGFR antibody for head and neck squamous cell carcinoma (HNSCC), has displayed limited efficacy due to the emergence of intrinsic and acquired resistance. We and others have demonstrated that cetuximab resistance in HNSCC is driven by alternative receptor tyrosine kinases (RTK), includ...

journal_title：Cancer research

authors： Leonard B,Brand TM,O'Keefe RA,Lee ED,Zeng Y,Kemmer JD,Li H,Grandis JR,Bhola NE

更新日期：2018-08-01 00:00:00

abstract：:Although radiotherapy (RT) decreases the incidence of locoregional recurrence in breast cancer, patients with triple-negative breast cancer (TNBC) have increased risk of local recurrence following breast-conserving therapy. The relationship between RT and local recurrence is unknown. Here, we tested the hypothesis tha...

journal_title：Cancer research

authors： Rafat M,Aguilera TA,Vilalta M,Bronsart LL,Soto LA,von Eyben R,Golla MA,Ahrari Y,Melemenidis S,Afghahi A,Jenkins MJ,Kurian AW,Horst KC,Giaccia AJ,Graves EE

更新日期：2018-08-01 00:00:00

abstract：:Homozygous deletion of the methylthioadenosine phosphorylase (MTAP) gene is a frequent event in a wide variety of human cancers and is a possible molecular target for therapy. One potential therapeutic strategy to target MTAP-deleted tumors involves combining toxic purine analogues such as 6'-thioguanine (6TG) or 2'-f...

journal_title：Cancer research

authors： Tang B,Lee HO,An SS,Cai KQ,Kruger WD

更新日期：2018-08-01 00:00:00

abstract：:Despite esophageal adenocarcinoma (EAC) being the most widespread among gastrointestinal cancers, with an 11-fold increase in the risk of cancer for patients with Barrett esophagus (BE), its prognosis is still poor. There is a critical need to better perceive the biology of cancer progression and identification of spe...

journal_title：Cancer research

authors： Urbanska AM,Ponnazhagan S,Mozafari M

更新日期：2018-07-15 00:00:00

abstract：:Ras signaling originates from transient nanoscale compartmentalized regions of the plasma membrane composed of specific proteins and lipids. The highly specific lipid composition of these nanodomains, termed nanoclusters, facilitates effector recruitment and therefore influences signal transduction. This suggests that...

journal_title：Cancer research

authors： Fuentes NR,Mlih M,Barhoumi R,Fan YY,Hardin P,Steele TJ,Behmer S,Prior IA,Karpac J,Chapkin RS

更新日期：2018-07-15 00:00:00

abstract：:The production of CD73-derived adenosine (Ado) by Tregs has been proposed as a resistance mechanism to anti-PD-1 therapy in murine tumor models. We reported that human Tregs express the ectonucleotidase CD39, which generates AMP from ATP, but do not express the AMPase CD73. In contrast, CD73 defined a subset of effect...

journal_title：Cancer research

authors： Gourdin N,Bossennec M,Rodriguez C,Vigano S,Machon C,Jandus C,Bauché D,Faget J,Durand I,Chopin N,Tredan O,Marie JC,Dubois B,Guitton J,Romero P,Caux C,Ménétrier-Caux C

更新日期：2018-07-01 00:00:00

abstract：:The development of myeloid and lymphoid neoplasms related to overexpression of FGFR1 kinases as a result of chromosome translocations depends on the promotion of a stem cell phenotype, suppression of terminal differentiation, and resistance to apoptosis. These phenotypes are related to the stem cell leukemia/lymphoma ...

journal_title：Cancer research

authors： Hu T,Chong Y,Lu S,Wang R,Qin H,Silva J,Kitamura E,Chang CS,Hawthorn L,Cowell JK

更新日期：2018-07-01 00:00:00

abstract：:The high mortality of pancreatic cancer demands that new therapeutic avenues be developed. The orally available small-molecule inhibitor AT13148 potently inhibits ROCK1 and ROCK2 kinases that regulate the actomyosin cytoskeleton. We previously reported that ROCK kinase expression increases with human and mouse pancrea...

journal_title：Cancer research

authors： Rath N,Munro J,Cutiongco MF,Jagiełło A,Gadegaard N,McGarry L,Unbekandt M,Michalopoulou E,Kamphorst JJ,Sumpton D,Mackay G,Vennin C,Pajic M,Timpson P,Olson MF

更新日期：2018-06-15 00:00:00

abstract：:Mounting clinical and preclinical evidence supports a key role for sustained adrenergic signaling in the tumor microenvironment as a driver of tumor growth and progression. However, the mechanisms by which adrenergic neurotransmitters are delivered to the tumor microenvironment are not well understood. Here we present...

journal_title：Cancer research

authors： Allen JK,Armaiz-Pena GN,Nagaraja AS,Sadaoui NC,Ortiz T,Dood R,Ozcan M,Herder DM,Haemmerle M,Gharpure KM,Rupaimoole R,Previs RA,Wu SY,Pradeep S,Xu X,Han HD,Zand B,Dalton HJ,Taylor M,Hu W,Bottsford-Miller J,Moreno

更新日期：2018-06-15 00:00:00

abstract：:Loss of the short arm of chromosome 3 (3p) occurs early in >95% of clear cell renal cell carcinoma (ccRCC). Nearly ubiquitous 3p loss in ccRCC suggests haploinsufficiency for 3p tumor suppressors as early drivers of tumorigenesis. We previously reported methyltransferase SETD2, which trimethylates H3 histones on lysin...

journal_title：Cancer research

authors： Chiang YC,Park IY,Terzo EA,Tripathi DN,Mason FM,Fahey CC,Karki M,Shuster CB,Sohn BH,Chowdhury P,Powell RT,Ohi R,Tsai YS,de Cubas AA,Khan A,Davis IJ,Strahl BD,Parker JS,Dere R,Walker CL,Rathmell WK

更新日期：2018-06-15 00:00:00

abstract：:Somatic copy number variations (CNV) may drive cancer progression through both coding and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely unknown, especially for circular RNAs. By integrating bioinformatics analyses of alerted circRNAs and focal CNV in lung adenocarcinoma, we ident...

journal_title：Cancer research

authors： Qiu M,Xia W,Chen R,Wang S,Xu Y,Ma Z,Xu W,Zhang E,Wang J,Fang T,Hu J,Dong G,Yin R,Wang J,Xu L

更新日期：2018-06-01 00:00:00

abstract：:Glycosylation, a posttranslational modification, has a major role in recombinant anticancer therapeutic proteins, as most of the approved recombinant therapeutics are glycoproteins. The constant amino acid sequence of therapeutics determines the enzymatic activity, while the presence of glycans influences their pharma...

journal_title：Cancer research

authors： Nadeem T,Khan MA,Ijaz B,Ahmed N,Rahman ZU,Latif MS,Ali Q,Rana MA

更新日期：2018-06-01 00:00:00

abstract：:The receptor-interacting protein kinase 1 (RIPK1) is an essential signaling molecule in pathways for cell survival, apoptosis, and necroptosis. We report here that RIPK1 is upregulated in human colorectal cancer and promotes cell proliferation when overexpressed in a colon cancer cell line. RIPK1 interacts with mitoch...

journal_title：Cancer research

authors： Zeng F,Chen X,Cui W,Wen W,Lu F,Sun X,Ma D,Yuan Y,Li Z,Hou N,Zhao H,Bi X,Zhao J,Zhou J,Zhang Y,Xiao RP,Cai J,Zhang X

更新日期：2018-06-01 00:00:00

abstract：:A growing number of observations has suggested that plasmacytoid dendritic cells (pDC) play a critical role in tumor biology. In patients, infiltration of tumors by pDCs generally correlates with a poor prognosis, suggesting that pDCs may play an important role in the host-tumor relationship. Here, we analyze the infl...

journal_title：Cancer research

authors： Terra M,Oberkampf M,Fayolle C,Rosenbaum P,Guillerey C,Dadaglio G,Leclerc C

更新日期：2018-06-01 00:00:00

abstract：:Inhibin is a heterodimeric TGFβ family ligand that is expressed in many cancers and is a selective biomarker for ovarian cancers; however, its tumor-specific functions remain unknown. Here, we demonstrate that the α subunit of inhibin (INHA), which is critical for the functionality of dimeric inhibin A/B, correlates w...

journal_title：Cancer research

authors： Singh P,Jenkins LM,Horst B,Alers V,Pradhan S,Kaur P,Srivastava T,Hempel N,Győrffy B,Broude EV,Lee NY,Mythreye K

更新日期：2018-06-01 00:00:00

abstract：:Multiple myeloma (MM) is a treatable, but incurable, malignancy of plasma cells (PC) in the bone marrow (BM). It represents the final stage in a continuum of PC dyscrasias and is consistently preceded by a premalignant phase termed monoclonal gammopathy of undetermined significance (MGUS). The existence of this well-d...

journal_title：Cancer research

authors： van Nieuwenhuijzen N,Spaan I,Raymakers R,Peperzak V

更新日期：2018-05-15 00:00:00

abstract：:The molecular pathways driving mesenchymal glioblastoma (GBM) are still not well understood. We report here that truncated glioma-associated oncogene homolog 1 (tGLI1) is a tumor-specific transcription factor that facilitates GBM growth, is enriched in the mesenchymal subtype of GBM and glioma stem cells (GSC), and pr...

journal_title：Cancer research

authors： Rimkus TK,Carpenter RL,Sirkisoon S,Zhu D,Pasche BC,Chan MD,Lesser GJ,Tatter SB,Watabe K,Debinski W,Lo HW

更新日期：2018-05-15 00:00:00

abstract：:Prostate cancer stem-like cells (PCSLC) are believed to be responsible for prostate cancer onset and metastasis. Autocrine and microenvironmental signals dictate PCSLC behavior and patient outcome. In prostate cancer patients, IL30/IL27p28 has been linked with tumor progression, but the mechanisms underlying this link...

journal_title：Cancer research

authors： Sorrentino C,Ciummo SL,Cipollone G,Caputo S,Bellone M,Di Carlo E

更新日期：2018-05-15 00:00:00